CMCC 1595

Topical application of Agonists for Neurotrophic Factor Receptors as a Treatment of Peripheral Neuropathies

Inventors: Gabriel Corfas, Joshua Murtie

Categories: Therapeutics

SubCategories: Endocrinology, Neurology/Neuroscience

Keywords: Drug Discovery

Invention Description:

Identification that the topical application of a small molecule, which mimics a known neurotrophic factor, can reverse and prevent the nerve damage underlying the pathophysiology of small fiber neuropathy. This is a serious, peripheral neuropathy commonly found in patients with diabetes mellitus, human immunodeficiency virus (HIV) infection, or those undergoing chemotherapy. There are no products currently available to treat the nerve damage; the current treatments (antidepressants, anticonvulsants, lidocaine patches) only alleviate the symptoms but do not treat the associated nerve damage.

Applications:

• Cancer (and effects of chemotherapy)
• Lupus
• Diabetes
• Shingles
• Alcoholism

Competitive Advantages:

Clear results, showing that this small molecule can anatomically restore nerve fibers and restore function in two specialized mouse model of genetic and induced neuropathyl. The topical use is expected to be safer and have fewer side effects than the oral administration. This is a large market opportunity, since it is a clear unmet need with high incidence. Growth in incidence anticipated with the aging of the population and increased incidence of neuropathies.

Business Opportunity:

• Exclusive License
• Partnerships for Development

Key Publications: Manuscript being finalized to be submitted for publication

IPStatus: Pat. Pend.