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CMCC 1595

A small molecule drug as a topical treatment for small fiber peripheral neuropathy

Inventors: Gabriel Corfas, Joshua Murtie

Categories: Therapeutics

SubCategories: Endocrinology-No Sub-Interest Specified, Neurology/Neuroscience-No Sub-Interest Specified

Keywords: Drug Discovery

Invention Description:

A small molecule that enhances ligand-induced signaling by the Glial Derived Neurotrophic Factor receptor (GFR-alpha/RET) family, which when applied topically in mouse models of small fiber peripheral neuropathy prevents nerve degeneration and preserves sensory function.

Applications:

Peripheral neuropathy is very prevalent and can be caused by many diseases and disorders. Applications include neuropathies caused by:

• Chemotherapy
• Cancer
• Lupus
• Diabetes
• Shingles
• Alcoholism

Competitive Advantages:

There are no products currently available to directly treat the underlying causes of nerve damage; the current treatments (antidepressants, anticonvulsants, lidocaine patches) only alleviate the symptoms but do not treat the associated nerve damage or address the disease that has neuropathy as a side effect. The topical use is expected to be safer and have fewer side effects than the oral administration.

Business Opportunity:

• Exclusive License
• Partnerships for Development

Key Publications: Manuscript in press (PNAS)

IPStatus: Patented

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